SNAKES VENOMS USED IN HEMATOLOGICAL LABORATORY TESTS

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 Hi friends, let us get back to something related to hematology in this post. We will see about the snake venoms used in hematology laboratory tests.

 

Sl.No

Snake

Common name

Scientific name

Commonly seen

Venom used

Principle

Laboratory test

1




Common  Lancehead

Bothrops atrox

South America (kills more humans than any other American snake)

Reptilase

Fibrinogen activator (uninhibited by antithrombin so unaffected by Heparin)

Reptilase time (commonly used to screen for heparin contamination of a plasma sample)

2




Copperhead

Agkistrodon contortrix

North America

Protac

Protein C activator

The basis for functional Protein C and S assays and for activated Protein C resistance

3






Russell Viper

Daboia russelii

Asia (kills more humans than any other snake)

Dilute Russells’s Viper Venom (dRVVT- test for lupus anticoagulant)

Activates factors V and X

dRVVT –test for lupus antocoagulant

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