Hematology all time.

  Von Willebrand disease (VWD) is an inherited bleeding disorder. There are evidence based guidelines from various societies like American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), the National Hemophilia Foundation (NHF) and the World Federation of Hemophilia (WFH) for the diagnosis of VWD. The Outcomes and Implementation Research unit at the University of Kansas Medical Centre (KUMC), supported the guideline-development process, including performing or updating systematic evidence reviews up to 8 January 2020. The panel prioritized clinical questions and outcomes according to their importance for clinicians and patients. The panel used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, including GRADE Evidence- to- Decision frameworks to assess evidence and make recommendations. The panel agreed on 11 recommendations:   Figure 1 shows the diagnostic algorithm for VWD Recommendation 1 For

  Dear friends, this is my Golden Jubilee post. I thank everyone for your constant support and motivation. As I already mentioned in my 25 th post, every 25 th post will be about one of my teachers or persons who inspired me. In this post, I would like to share a poetry ( I tried to write one)   which I wrote about one of my teachers who inspired and keeps inspiring me.   He, who taught me the ABC of cell morphology,       He, who taught me science and to understand its mysteries, He, who taught me what true pathology is, He, who taught me beyond books and atlases, He, who taught me to see the colours in cells, to see maturing myeloid cells as ripening mango, megaloblastic erythroid maturation as broken bassin ka laddu, He, who taught me what a giant myelocyte, metamyelocyte is, He, who taught me English grammar, He, who taught me how to write an article, a project proposal, He, who taught me the difference between evidence & presence of, He, who taught me h

Dear friends, Wishing you a very happy and prosperous New Year 2021. Hairy cell leukemia (HCL) is a chronic B- cell lymphoid malignancy that has always fascinated hematologists and pathologists. In this post, we shall see about the history of hairy cell leukemia with landmark papers. Year Description Landmark papers 1952 Reticular cell leukemia: A clinical hematologic entity- described 17 patients with typical features of HCL presented at a meeting at American Society for Clinical Pathology. Rosenthal 1958 Classical description of the disease as Leukaemic Reticulo-endotheliosis and the benefits of splenectomy. Bouroncle et al 1966 Introduction of the term ‘Hairy cell’ Schrek and Donelly 1966 Demonstration of the characteristic bone marrow fibrosis in HCL Duhamel and Guerra 1971 Showed