Hematology all time.

  June 19 is observed as world Sickle cell disease     and celebrated globally to raise awareness about Sickle cell disease. The theme  is “Shine the light on Sickle cell”. In this post let me shine some light on “Hydroxyurea in Sickle cell disease”.  Properties Hydroxyurea   Drug class Antimetabolite  Mechanism of action  Inhibition of ribonucleotide reductase (RR)  Increases HbF production Pharmacology  Half-life :4 hours  Potential benefits  ·        Improved survival & increased life expectancy ·        Decreased venoocclusive pain  ·        Decreased Acute coronary syndrome episodes  ·        Decreased transfusions ·        Decreased priapism episodes  ·        Preserve splenic function in infants  ·        Improved quality of life and daily functioning    Beneficial  In HbSS or HBs/ Beta 0  thalassemia genotypes Standard indications – Can be given at any age  from 6 month old infants to adults ·         Frequent pain crises ·         Acute chest syndrome ·         Severe or s

Hi friends, This post is regarding one of the rarer side effects of COVID 19 vaccine. Last year, with the onset of COVID pandemic, we were all eagerly looking for a solution and it was vaccine. Now we have so many vaccines, available from different brands, and they have been proven to be highly safe and effective. In late February 2021, a prothrombotic syndrome was observed in a small number of individuals who received certain adenoviral vector-based vaccines to COVID 19 Implicated vaccines: Ø   ChAdOx1 CoV- 19 vaccine (AstraZeneca, University of Oxford and Serum Institute of India) Ø   Ad26.COV2.S vaccine (Janssen;Johnson & Johnson) This syndrome was named as vaccine –indced immune thrombotic thrombocytopenia(VITT). The other names are -       thrombosis with thrombocytopenia syndrome (TTS) and -       vaccine- indced prothrombotic   immune thrombocytopenia(VIPIT) We shall talk about the salient features of VITT in this post Pathophysiology :   VITT is caus

  June 14 is celebrated as World Blood Donor Day (WBDD) throughout the world every year to spread awareness on the importance of blood donation, need for safe blood and blood products for transfusion and also to recognize the critical contribution of voluntary unpaid blood donors in saving lives.  This year WBDD is hosted by Italy in Rome.   You know why June 14 was chosen?  June 14 is the birthday of Austrian biologist and physician Karl Landsteiner who is the founder of modern blood transfusion. The theme of WBDD 2021 is : “Give blood and keep the world beating”.  The specific objectives of this year’s campaign by WHO are to: thank blood donors in the world and create wider public awareness of the need for regular, unpaid blood donation promote the community values of blood donation in enhancing community solidarity and social cohesion encourage youth to embrace the humanitarian call to donate blood and inspire others to do the same celebrate the potential of youth as partners in pro